Creates a VPC plot from observed and simulation data for censored data. Function can handle both left- (below lower limit of quantification) and right-censored (above upper limit of quantification) data.
Usage
vpc_cens(
sim = NULL,
obs = NULL,
psn_folder = NULL,
bins = "jenks",
n_bins = 8,
bin_mid = "mean",
obs_cols = NULL,
sim_cols = NULL,
software = "auto",
show = NULL,
stratify = NULL,
stratify_color = NULL,
ci = c(0.05, 0.95),
uloq = NULL,
lloq = NULL,
xlab = "Time",
ylab = "Probability of <LOQ",
title = NULL,
smooth = TRUE,
vpc_theme = NULL,
facet = "wrap",
labeller = NULL,
vpcdb = FALSE,
verbose = FALSE
)Arguments
- sim
this is usually a data.frame with observed data, containing the independent and dependent variable, a column indicating the individual, and possibly covariates. E.g. load in from NONMEM using read_table_nm. However it can also be an object like a nlmixr or xpose object
- obs
a data.frame with observed data, containing the independent and dependent variable, a column indicating the individual, and possibly covariates. E.g. load in from NONMEM using read_table_nm
- psn_folder
instead of specifying "sim" and "obs", specify a PsN-generated VPC-folder
- bins
either "density", "time", or "data", "none", or one of the approaches available in classInterval() such as "jenks" (default) or "pretty", or a numeric vector specifying the bin separators.
- n_bins
when using the "auto" binning method, what number of bins to aim for
- bin_mid
either "mean" for the mean of all timepoints (default) or "middle" to use the average of the bin boundaries.
- obs_cols
list for mapping observation data columns, e.g. `list(dv = "DV", id = "ID", idv = "TIME", pred="PRED")`
- sim_cols
list for mapping simulation data columns, e.g. `list(dv = "DV", id = "ID", idv = "TIME", pred="PRED")`
- software
name of software platform using (e.g. nonmem, phoenix)
- show
what to show in VPC (obs_dv, obs_ci, pi, pi_as_area, pi_ci, obs_median, sim_median, sim_median_ci)
- stratify
character vector of stratification variables. Only 1 or 2 stratification variables can be supplied.
- stratify_color
variable to stratify and color lines for observed data. Only 1 stratification variables can be supplied.
- ci
confidence interval to plot. Default is (0.05, 0.95)
- uloq
Number or NULL indicating upper limit of quantification. Default is NULL.
- lloq
Number or NULL indicating lower limit of quantification. Default is NULL.
- xlab
label for x axis
- ylab
label for y axis
- title
title
- smooth
"smooth" the VPC (connect bin midpoints) or show bins as rectangular boxes. Default is TRUE.
- vpc_theme
theme to be used in VPC. Expects list of class vpc_theme created with function vpc_theme()
- facet
either "wrap", "columns", or "rows"
- labeller
ggplot2 labeller function to be passed to underlying ggplot object
- vpcdb
boolean whether to return the underlying vpcdb rather than the plot
- verbose
show debugging information (TRUE or FALSE)
