Design dose-reponse trials

Mods() getResp() plotMods() plot(<Mods>)

Define dose-response models

guesst()

Calculate guesstimates based on prior knowledge

optContr() plot(<optContr>) plotContr()

Calculate optimal contrasts

optDesign() calcCrit() rndDesign() plot(<DRdesign>)

Function to calculate optimal designs

planMod() summary(<planMod>) plot(<planMod>)

Evaluate performance metrics for fitting dose-response models

powMCT()

Calculate power for multiple contrast test

sampSize() sampSizeMCT() targN() powN() plot(<targN>)

Sample size calculations

DesignMCPModApp()

Start externally hosted DesignMCPMod Shiny App

Analyze dose-response trials

MCPMod() predict(<MCPMod>) plot(<MCPMod>)

MCPMod - Multiple Comparisons and Modeling

MCTpval()

Calculate multiplicity adjusted p-values for multiple contrast test

MCTtest()

Performs multiple contrast test

bMCTtest()

Performs Bayesian multiple contrast test

powMCTInterim()

Calculate Conditional or Predictive Power for Multiple Contrast Test

critVal()

Calculate critical value for multiple contrast test

mvpostmix()

Prior to posterior updating for a multivariate normal mixture

mvtnorm.control()

Control options for pmvt and qmvt functions

Fit dose-response model

bFitMod() coef(<bFitMod>) predict(<bFitMod>) plot(<bFitMod>)

Fit a dose-response model using Bayesian or bootstrap methods.

defBnds()

Calculates default bounds for non-linear parameters in dose-response models

emax() emaxGrad() sigEmax() sigEmaxGrad() exponential() exponentialGrad() quadratic() quadraticGrad() betaMod() betaModGrad() linear() linearGrad() linlog() linlogGrad() logistic() logisticGrad() linInt() linIntGrad()

Built-in dose-response models in DoseFinding

fitMod() coef(<DRMod>) vcov(<DRMod>) predict(<DRMod>) plot(<DRMod>) logLik(<DRMod>) AIC(<DRMod>) gAIC(<DRMod>)

Fit non-linear dose-response model

maFitMod() predict(<maFit>) plot(<maFit>)

Fit dose-response models via bootstrap model averaging (bagging)

TD() ED()

Calculate dose estimates for a fitted dose-response model (via fitMod(), bFitMod()) or maFitMod()) or a Mods() object

Datasets

biom

Biometrics Dose Response data

glycobrom

Glycopyrronium Bromide dose-response data

IBScovars

Irritable Bowel Syndrome Dose Response data with covariates

migraine

Migraine Dose Response data

neurodeg

Neurodegenerative disease simulated longitudinal dose-finding data set