Rat treatment data from Mantel et al

Rat treatment data from Mantel et al. Three rats were chosen from each of 100 litters, one of which was treated with a drug, and then all followed for tumor incidence.

Usage

rats
data(cancer, package="survival")

Format

litter:	litter number from 1 to 100
rx:	treatment,(1=drug, 0=control)
time:	time to tumor or last follow-up
status:	event status, 1=tumor and 0=censored
sex:	male or female

Source

N. Mantel, N. R. Bohidar and J. L. Ciminera. Mantel-Haenszel analyses of litter-matched time to response data, with modifications for recovery of interlitter information. Cancer Research, 37:3863-3868, 1977.

References

E. W. Lee, L. J. Wei, and D. Amato, Cox-type regression analysis for large number of small groups of correlated failure time observations, in "Survival Analysis, State of the Art", Kluwer, 1992.

Note

Since only 2/150 of the male rats have a tumor, most analyses use only females (odd numbered litters), e.g. Lee et al.