Chronic Myelogenous Leukemia survival data.

Survival in a randomised trial comparing three treatments for Chronic Myelogeneous Leukemia (simulated data).

Usage

data("cml")

Format

A data frame with 507 observations on the following 7 variables.

center: a factor with 54 levels indicating the study center.
treatment: a factor with levels trt1, trt2, trt3 indicating the treatment group.
sex: sex (0 = female, 1 = male)
age: age in years
riskgroup: risk group (0 = low, 1 = medium, 2 = high)
status: censoring status (FALSE = censored, TRUE = dead)
time: survival or censoring time in days.

Details

The data are simulated according to structure of the data by the German CML Study Group used in hehlmann1994.

References

Examples


if (require("coxme")) {
    data("cml")
    ### one-sided simultaneous confidence intervals for many-to-one 
    ### comparisons of treatment effects concerning time of survival 
    ### modeled by a frailty Cox model with adjustment for further 
    ### covariates and center-specific random effect.
    cml_coxme <- coxme(Surv(time, status) ~ treatment + sex + age + riskgroup + (1|center), 
                       data = cml)
    glht_coxme <- glht(model = cml_coxme, linfct = mcp(treatment = "Dunnett"), 
                       alternative = "greater")
    ci_coxme <- confint(glht_coxme)
    exp(ci_coxme$confint)[1:2,]
}
#> Loading required package: coxme
#> Loading required package: bdsmatrix
#> 
#> Attaching package: ‘bdsmatrix’
#> The following object is masked from ‘package:base’:
#> 
#>     backsolve
#>             Estimate      lwr upr
#> trt2 - trt1 1.551055 1.184052 Inf
#> trt3 - trt1 1.396362 1.068766 Inf