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Convert pharmacokinetic parameters for two compartment model

TwoComp_Volume_RateConstant.Rd

Calculate pharmacokinetic parameters with volume of distribution (V1), elimination rate constant (k10), and transter rate constants (k12, k21)

Usage

TwoComp_Volume_RateConstant(V1,k10,k12,k21,
              V1.sd=NA,k10.sd=NA,k12.sd=NA,k21.sd=NA,
              covar=c(V1k10=NA,V1k12=NA,V1k21=NA,
              k10k12=NA,k10k21=NA,k12k21=NA),...)

Arguments

V1

The volume of distribution of compartment 1

k10

elimination rate constant

k12

transfer rate constants from compartment 1 to compartment 2

k21

transfer rate constants from compartment 2 to compartment 1

V1.sd

standard error of V1

k10.sd

standard error of k10

k12.sd

standard error of k12

k21.sd

standard error of k21

covar

covariances among parameters

...

arguments to be passed to methods

References

http://www.nonmemcourse.com/convert.xls

Examples

TwoComp_Volume_RateConstant(V1=5,k10=0.7,k12=0.5,k21=0.05,
         V1.sd=0.01,k10.sd=0.002,k12.sd=0.001,k21.sd=0.0005)
#>         Parameter     Estimate      Std.err
#> Vdss         Vdss 55.000000000 5.216321e-01
#> V1             V1  5.000000000 1.000000e-02
#> V2             V2 50.000000000 5.196152e-01
#> Cl1           Cl1  3.500000000 1.220656e-02
#> Cl2           Cl2  2.500000000 5.590170e-03
#> k10           k10  0.700000000 2.000000e-03
#> k12           k12  0.500000000 1.000000e-03
#> k21           k21  0.050000000 5.000000e-04
#> alpha       alpha  1.221343022 2.225875e-03
#> beta         beta  0.028656978 2.847238e-04
#> t_alpha   t_alpha  0.567528670 1.034311e-03
#> t_beta     t_beta 24.187727779 2.403192e-01
#> True_A     True_A  0.196421016 3.947426e-04
#> True_B     True_B  0.003578984 3.934534e-05
#> Frac_A     Frac_A  0.982105079 1.934437e-04
#> Frac_B     Frac_B  0.017894921 1.934437e-04