Convert pharmacokinetic parameters for three compartment model

Calculate pharmacokinetic parameters with volume of distributions (V1, V2 and V3) and clearances (Cl1, Cl2, and Cl3)

Usage

ThreeComp_Volume_Clearance(V1,V2,V3,Cl1,Cl2,Cl3,
 V1.sd=NA,V2.sd=NA,V3.sd=NA, Cl1.sd=NA,Cl2.sd=NA,Cl3.sd=NA,
 covar=c(V1V2=NA,V1V3=NA,V1Cl1=NA,
   V1Cl2=NA,V1Cl3=NA,V2V3=NA,V2Cl1=NA,V2Cl2=NA,V2Cl3=NA,
   V3Cl1=NA,V3Cl2=NA,V3Cl3=NA,Cl1Cl2=NA,Cl1Cl3=NA,Cl2Cl3=NA),...)

Arguments

V1

The volume of distribution of compartment 1

V2

The volume of distribution of compartment 2

V3

The volume of distribution of compartment 3

Cl1

Clearance from compartment 1

Cl2

Clearance from compartment 2

Cl3

Clearance from compartment 3

V1.sd

standard error of V1

V2.sd

standard error of V2

V3.sd

standard error of V3

Cl1.sd

standard error of Cl1

Cl2.sd

standard error of Cl2

Cl3.sd

standard error of Cl3

covar

covariances among parameters

...

arguments to be passed to methods

References

http://www.nonmemcourse.com/convert.xls

Examples

ThreeComp_Volume_Clearance(V1=10,V2=100,V3=1000,Cl1=3,Cl2=2,Cl3=1,
  V1.sd=0.01,V2.sd=0.1,V3.sd=1,Cl1.sd=0.01,Cl2.sd=0.01,Cl3.sd=0.01)
#>         Parameter     Estimate      Std.err
#> Vdss         Vdss 1.110000e+03 1.005037e+00
#> V1             V1 1.000000e+01 1.000000e-02
#> V2             V2 1.000000e+02 1.000000e-01
#> V3             V3 1.000000e+03 1.000000e+00
#> Cl1           Cl1 3.000000e+00 1.000000e-02
#> Cl2           Cl2 2.000000e+00 1.000000e-02
#> Cl3           Cl3 1.000000e+00 1.000000e-02
#> k10           k10 3.000000e-01 1.044031e-03
#> k12           k12 2.000000e-01 1.019804e-03
#> k21           k21 2.000000e-02 1.019804e-04
#> k13           k13 1.000000e-01 1.004988e-03
#> k31           k31 1.000000e-03 1.004988e-05
#> alpha       alpha 6.069796e-01 1.853743e-03
#> beta         beta 1.327584e-02 4.828835e-05
#> gamma       gamma 7.445863e-04 5.588798e-06
#> t_alpha   t_alpha 1.141961e+00 3.487601e-03
#> t_beta     t_beta 5.221116e+01 1.899081e-01
#> t_gamma   t_gamma 9.309159e+02 6.987371e+00
#> True_A     True_A 9.882577e-02 1.004599e-04
#> True_B     True_B 1.109493e-03 9.499952e-06
#> True_C     True_C 6.473832e-05 1.032739e-06
#> Frac_A     Frac_A 9.882577e-01 9.303920e-05
#> Frac_B     Frac_B 1.109493e-02 9.568604e-05
#> Frac_C     Frac_C 6.473832e-04 1.034778e-05