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Convert pharmacokinetic parameters for three compartment model

ThreeComp_Coefficient_Exponent.Rd

Calculate pharmacokinetic parameters with parameters (A, B, C, alpha, beta, and gamma) in two compartment model "Aexp(-alpha)+Bexp(-beta)+Cexp(-gamma)"

Usage

ThreeComp_Coefficient_Exponent(A,B,C,alpha,beta,gamma,A.sd=NA,
   B.sd=NA,C.sd=NA,alpha.sd=NA,beta.sd=NA,gamma.sd=NA,
   covar=c(AB=NA,AC=NA,Aalpha=NA,Abeta=NA,Agamma=NA,BC=NA,Balpha=NA,
   Bbeta=NA,Bgamma=NA,Calpha=NA,Cbeta=NA,Cgamma=NA,alphabeta=NA,
   alphagamma=NA,betagamma=NA),...)

Arguments

A

parameter in one compartment model "Aexp(-alpha)"

B

parameter in two compartment model "Aexp(-alpha)+Bexp(-beta)"

C

parameter in three compartment model "Aexp(-alpha)+Bexp(-beta)+Cexp(-gamma)"

alpha

parameter in one compartment model "Aexp(-alpha)"

beta

parameter in two compartment model "Aexp(-alpha)+Bexp(-beta)"

gamma

parameter in three compartment model "Aexp(-alpha)+Bexp(-beta)+Cexp(-gamma)"

A.sd

standard error of A

B.sd

standard error of B

C.sd

standard error of C

alpha.sd

standard error of alpha

beta.sd

standard error of beta

gamma.sd

standard error of gamma

covar

covariances among parameters

...

arguments to be passed to methods

References

http://www.nonmemcourse.com/convert.xls

Examples

ThreeComp_Coefficient_Exponent(A=12.2,B=3.76,C=1.44,
alpha=0.870,beta=0.12,gamma=0.013, A.sd=0.2,B.sd=0.005,C.sd=0.0005,
alpha.sd=0.009,beta.sd=0.006,gamma.sd=0.00005)
#>         Parameter     Estimate      Std.err
#> Vdss         Vdss  0.360938323 6.474356e-03
#> V1             V1  0.057471264 6.607977e-04
#> V2             V2  0.064978278 2.491319e-03
#> V3             V3  0.238488780 9.000084e-03
#> Cl1           Cl1  0.006405101 6.757429e-05
#> Cl2           Cl2  0.021376282 6.971502e-04
#> Cl3           Cl3  0.008828208 5.749821e-04
#> k10           k10  0.111448765 1.613078e-03
#> k12           k12  0.371947306 1.144533e-02
#> k21           k21  0.328975813 5.190621e-03
#> k13           k13  0.153610825 1.007924e-02
#> k31           k31  0.037017290 1.075726e-03
#> alpha       alpha  0.870000000 9.000000e-03
#> beta         beta  0.120000000 6.000000e-03
#> gamma       gamma  0.013000000 5.000000e-05
#> t_alpha   t_alpha  0.796720897 8.241940e-03
#> t_beta     t_beta  5.776226505 2.888113e-01
#> t_gamma   t_gamma 53.319013889 2.050731e-01
#> True_A     True_A 12.200000000 2.000000e-01
#> True_B     True_B  3.760000000 5.000000e-03
#> True_C     True_C  1.440000000 5.000000e-04
#> Frac_A     Frac_A  0.701149425 3.441027e-03
#> Frac_B     Frac_B  0.216091954 2.494017e-03
#> Frac_C     Frac_C  0.082758621 9.519107e-04