Convert pharmacokinetic parameters for one compartment model — OneComp_Volume_Clearance

Calculate pharmacokinetic parameters with clearance (Cl1) and half-life (t_alpha)

Usage

OneComp_Volume_Clearance_HalfLife(Cl1,t_alpha,
         Cl1.sd=NA,t_alpha.sd=NA,covar=c(Cl1talpha=NA),...)

Arguments

Cl1: Clearance from compartment 1
t_alpha: half life of compartment 1
Cl1.sd: standard error of Cl1
t_alpha.sd: standard error of t_alpha
covar: covariances among parameters
...: arguments to be passed to methods

References

http://www.nonmemcourse.com/convert.xls

Examples

OneComp_Volume_Clearance_HalfLife(Cl1=4,t_alpha=0.568,
      Cl1.sd=0.01,t_alpha.sd=0.0003)
#>         Parameter  Estimate      Std.err
#> Vdss         Vdss 3.2778031 0.0083753883
#> V1             V1 3.2778031 0.0083753883
#> Cl1           Cl1 4.0000000 0.0100000000
#> k10           k10 1.2203295 0.0006445403
#> alpha       alpha 1.2203295 0.0006445403
#> t_alpha   t_alpha 0.5680000 0.0003000000
#> True_A     True_A 0.3050824 0.0007795415
#> Frac_A     Frac_A 1.0000000 0.0000000000