Simplest NCA
sNCA.RdThis is the work-horse function for NCA.
Usage
sNCA(x, y, dose = 0, adm = "Extravascular", dur = 0, doseUnit = "mg", timeUnit = "h",
concUnit = "ug/L", iAUC = "", down = "Linear", R2ADJ = 0.7, MW = 0, SS = FALSE,
Keystring="", excludeDelta = 1, UsePoints = NULL)Arguments
- x
usually time, a vector
- y
usually concentration, a vector
- dose
given amount, not amount per body weight, a scalar
- adm
one of
"Bolus"or"Infusion"or"Extravascular"to indicate drug administration mode- dur
duration of infusion, a scalar
- doseUnit
unit of dose
- timeUnit
unit of time
- concUnit
unit of concentration
- iAUC
interval AUCs to calculate
- down
either of
"Linear"or"Log"to indicate the way to calculate AUC and AUMC- R2ADJ
Minimum adjusted R-square value to determine terminal slope automatically
- MW
molecular weight of the drug
- SS
if steady-state, this should be TRUE. AUCLST (AUClast) is used instead of AUCIFO (AUCinf) for the calculation of Vz (VZFO, VZO), CL (CLFO, CLO), and Vdss (VSSO).
- Keystring
a text string to be shown at the plot in case of manual selection of terminal slope
- excludeDelta
Improvement of R2ADJ larger than this value could exclude the last point. Default value 1 is for the compatibility with other software.
- UsePoints
Indices of points to calculate terminal slope. Vaules of use points should not be zero. Use only when automatic determination is not satisfactory. If this is used, R2ADJ option is ignored.
Details
This replaced previous IndiNCA. Author recommends to use excludeDelta option with about 0.3.
Value
- CMAX
maximum concentration, Cmax
- CMAXD
dose normalized Cmax, CMAX / Dose, Cmax / Dose
- TMAX
time of maximum concentration, Tmax
- TLAG
time to observe the first non-zero concentration, for extravascular administration only
- CLST
last positive concentration observed, Clast
- CLSTP
last positive concentration predicted, Clast_pred
- TLST
time of last positive concentration, Tlast
- LAMZHL
half-life by lambda z, ln(2)/LAMZ
- LAMZ
lambda_z negative of the best-fit terminal slope
- LAMZLL
earliest time for LAMZ
- LAMZUL
last time for LAMZ
- LAMZNPT
number of points for LAMZ
- CORRXY
correlation of log(concentration) and time
- R2
R-squared
- R2ADJ
R-squared adjusted
- C0
back extrapolated concentration at time 0, for intravascular bolus administration only
- AUCLST
AUC from 0 to TLST
- AUCALL
AUC using all the given points, including trailing zero concentrations
- AUCIFO
AUC infinity observed
- AUCIFOD
AUCIFO / Dose
- AUCIFP
AUC infinity predicted using CLSTP instead of CLST
- AUCIFPD
AUCIFP / Dose
- AUCPEO
AUC % extrapolation observed
- AUCPEP
AUC % extrapolated for AUCIFP
- AUCPBEO
AUC % back extrapolation observed, for bolus IV administration only
- AUCPBEP
AUC % back extrapolation predicted with AUCIFP, for bolus IV administration only
- AUMCLST
AUMC to the TLST
- AUMCIFO
AUMC infinity observed using CLST
- AUMCIFP
AUMC infinity determined by CLSTP
- AUMCPEO
AUMC % extrapolated observed
- AUMCPEP
AUMC % extrapolated predicted
- MRTIVLST
mean residence time (MRT) to TLST, for intravascular administration
- MRTIVIFO
mean residence time (MRT) infinity using CLST, for intravascular administration
- MRTIVIFP
mean residence time (MRT) infinity using CLSTP, for intravascular administration
- MRTEVLST
mean residence time (MRT) to TLST, for extravascular administration
- MRTEVIFO
mean residence time (MRT) infinity using CLST, for extravascular administration
- MRTEVIFP
mean residence time (MRT) infinity using CLSTP, for extravascular administration
- VZO
volume of distribution determined by LAMZ and AUCIFO, for intravascular administration
- VZP
volume of distribution determined by LAMZ and AUCIFP, for intravascular administration
- VZFO
VZO for extravascular administration, VZO/F, F is bioavailability
- VZFP
VZP for extravascular administration, VZP/F, F is bioavailability
- CLO
clearance using AUCIFO, for intravascular administration
- CLP
clearance using AUCIFP, for intravascular administration
- CLFO
CLO for extravascular administration, CLO/F, F is bioavailability
- CLFP
CLP for extravascular administration, CLP/F, F is bioavailability
- VSSO
volume of distribution at steady state using CLST, for intravascular administration only
- VSSP
volume of distribution at steady state using CLSTP, for intravascular administration only
- units
An attribute to show units
- UsedPoints
An attribute to show indices of used points
References
Gabrielsson J, Weiner D. Pharmacokinetic and Pharmacodynamic Data Analysis - Concepts and Applications. 5th ed. 2016.
Examples
# For one subject
x = Theoph[Theoph$Subject=="1","Time"]
y = Theoph[Theoph$Subject=="1","conc"]
sNCA(x, y, dose=320, doseUnit="mg", concUnit="mg/L", timeUnit="h")
#> b0 CMAX CMAXD TMAX TLAG CLST
#> 2.3687851 10.5000000 0.0328125 1.1200000 0.0000000 3.2800000
#> CLSTP TLST LAMZHL LAMZ LAMZLL LAMZUL
#> 3.2801465 24.3700000 14.3043776 0.0484570 9.0500000 24.3700000
#> LAMZNPT CORRXY R2 R2ADJ AUCLST AUCALL
#> 3.0000000 -0.9999999 0.9999997 0.9999995 148.9230500 148.9230500
#> AUCIFO AUCIFOD AUCIFP AUCIFPD AUCPEO AUCPEP
#> 216.6119330 0.6769123 216.6149558 0.6769217 31.2489169 31.2498763
#> AUMCLST AUMCIFO AUMCIFP AUMCPEO AUMCPEP VZFO
#> 1459.0711035 4505.5348194 4505.6708646 67.6160287 67.6170065 30.4867482
#> VZFP CLFO CLFP MRTEVLST MRTEVIFO MRTEVIFP
#> 30.4863228 1.4772963 1.4772757 9.7974834 20.8000305 20.8003683
#> attr(,"units")
#> [1] "" "mg/L" "mg/L/mg" "h" "h" "mg/L"
#> [7] "mg/L" "h" "h" "/h" "h" "h"
#> [13] "" "" "" "" "h*mg/L" "h*mg/L"
#> [19] "h*mg/L" "h*mg/L/mg" "h*mg/L" "h*mg/L/mg" "%" "%"
#> [25] "h2*mg/L" "h2*mg/L" "h2*mg/L" "%" "%" "L"
#> [31] "L" "L/h" "L/h" "h" "h" "h"
#> attr(,"UsedPoints")
#> [1] 9 10 11
sNCA(x, y, dose=320, concUnit="mg/L")
#> b0 CMAX CMAXD TMAX TLAG CLST
#> 2.3687851 10.5000000 0.0328125 1.1200000 0.0000000 3.2800000
#> CLSTP TLST LAMZHL LAMZ LAMZLL LAMZUL
#> 3.2801465 24.3700000 14.3043776 0.0484570 9.0500000 24.3700000
#> LAMZNPT CORRXY R2 R2ADJ AUCLST AUCALL
#> 3.0000000 -0.9999999 0.9999997 0.9999995 148.9230500 148.9230500
#> AUCIFO AUCIFOD AUCIFP AUCIFPD AUCPEO AUCPEP
#> 216.6119330 0.6769123 216.6149558 0.6769217 31.2489169 31.2498763
#> AUMCLST AUMCIFO AUMCIFP AUMCPEO AUMCPEP VZFO
#> 1459.0711035 4505.5348194 4505.6708646 67.6160287 67.6170065 30.4867482
#> VZFP CLFO CLFP MRTEVLST MRTEVIFO MRTEVIFP
#> 30.4863228 1.4772963 1.4772757 9.7974834 20.8000305 20.8003683
#> attr(,"units")
#> [1] "" "mg/L" "mg/L/mg" "h" "h" "mg/L"
#> [7] "mg/L" "h" "h" "/h" "h" "h"
#> [13] "" "" "" "" "h*mg/L" "h*mg/L"
#> [19] "h*mg/L" "h*mg/L/mg" "h*mg/L" "h*mg/L/mg" "%" "%"
#> [25] "h2*mg/L" "h2*mg/L" "h2*mg/L" "%" "%" "L"
#> [31] "L" "L/h" "L/h" "h" "h" "h"
#> attr(,"UsedPoints")
#> [1] 9 10 11
iAUC = data.frame(Name=c("AUC[0-12h]","AUC[0-24h]"), Start=c(0,0), End=c(12,24))
sNCA(x, y, dose=320, doseUnit="mg", concUnit="mg/L", timeUnit="h", iAUC=iAUC)
#> b0 CMAX CMAXD TMAX TLAG CLST
#> 2.3687851 10.5000000 0.0328125 1.1200000 0.0000000 3.2800000
#> CLSTP TLST LAMZHL LAMZ LAMZLL LAMZUL
#> 3.2801465 24.3700000 14.3043776 0.0484570 9.0500000 24.3700000
#> LAMZNPT CORRXY R2 R2ADJ AUCLST AUCALL
#> 3.0000000 -0.9999999 0.9999997 0.9999995 148.9230500 148.9230500
#> AUCIFO AUCIFOD AUCIFP AUCIFPD AUCPEO AUCPEP
#> 216.6119330 0.6769123 216.6149558 0.6769217 31.2489169 31.2498763
#> AUMCLST AUMCIFO AUMCIFP AUMCPEO AUMCPEP VZFO
#> 1459.0711035 4505.5348194 4505.6708646 67.6160287 67.6170065 30.4867482
#> VZFP CLFO CLFP MRTEVLST MRTEVIFO MRTEVIFP
#> 30.4863228 1.4772963 1.4772757 9.7974834 20.8000305 20.8003683
#> AUC[0-12h] AUC[0-24h]
#> 91.7355220 147.6945866
#> attr(,"units")
#> [1] "" "mg/L" "mg/L/mg" "h" "h" "mg/L"
#> [7] "mg/L" "h" "h" "/h" "h" "h"
#> [13] "" "" "" "" "h*mg/L" "h*mg/L"
#> [19] "h*mg/L" "h*mg/L/mg" "h*mg/L" "h*mg/L/mg" "%" "%"
#> [25] "h2*mg/L" "h2*mg/L" "h2*mg/L" "%" "%" "L"
#> [31] "L" "L/h" "L/h" "h" "h" "h"
#> [37] "h*mg/L" "h*mg/L"
#> attr(,"UsedPoints")
#> [1] 9 10 11
MW = 180.164 # Molecular weight of theophylline
sNCA(x, y/MW, dose=320, doseUnit="mg", concUnit="mmol/L", timeUnit="h")
#> Warning: Molecular weight should be given for more informative results!
#> b0 CMAX CMAXD TMAX TLAG
#> -2.8250824530 0.0582802336 0.0001821257 1.1200000000 0.0000000000
#> CLST CLSTP TLST LAMZHL LAMZ
#> 0.0182056349 0.0182064479 24.3700000000 14.3043775711 0.0484569970
#> LAMZLL LAMZUL LAMZNPT CORRXY R2
#> 9.0500000000 24.3700000000 3.0000000000 -0.9999998648 0.9999997297
#> R2ADJ AUCLST AUCALL AUCIFO AUCIFOD
#> 0.9999994593 0.8265971559 0.8265971559 1.2023041953 0.0037572006
#> AUCIFP AUCIFPD AUCPEO AUCPEP AUMCLST
#> 1.2023209731 0.0037572530 31.2489169405 31.2498763313 8.0985718762
#> AUMCIFO AUMCIFP AUMCPEO AUMCPEP VZFO
#> 25.0079639629 25.0087190814 67.6160286851 67.6170064935 NA
#> VZFP CLFO CLFP MRTEVLST MRTEVIFO
#> NA NA NA 9.7974833547 20.8000305256
#> MRTEVIFP
#> 20.8003683211
#> attr(,"units")
#> [1] "" "mmol/L" "mmol/L/mg" "h" "h"
#> [6] "mmol/L" "mmol/L" "h" "h" "/h"
#> [11] "h" "h" "" "" ""
#> [16] "" "h*mmol/L" "h*mmol/L" "h*mmol/L" "h*mmol/L/mg"
#> [21] "h*mmol/L" "h*mmol/L/mg" "%" "%" "h2*mmol/L"
#> [26] "h2*mmol/L" "h2*mmol/L" "%" "%" "L"
#> [31] "L" "L/h" "L/h" "h" "h"
#> [36] "h"
#> attr(,"UsedPoints")
#> [1] 9 10 11
sNCA(x, y/MW, dose=320, doseUnit="mg", concUnit="mmol/L", timeUnit="h", MW=MW)
#> b0 CMAX CMAXD TMAX TLAG
#> -2.8250824530 0.0582802336 0.0001821257 1.1200000000 0.0000000000
#> CLST CLSTP TLST LAMZHL LAMZ
#> 0.0182056349 0.0182064479 24.3700000000 14.3043775711 0.0484569970
#> LAMZLL LAMZUL LAMZNPT CORRXY R2
#> 9.0500000000 24.3700000000 3.0000000000 -0.9999998648 0.9999997297
#> R2ADJ AUCLST AUCALL AUCIFO AUCIFOD
#> 0.9999994593 0.8265971559 0.8265971559 1.2023041953 0.0037572006
#> AUCIFP AUCIFPD AUCPEO AUCPEP AUMCLST
#> 1.2023209731 0.0037572530 31.2489169405 31.2498763313 8.0985718762
#> AUMCIFO AUMCIFP AUMCPEO AUMCPEP VZFO
#> 25.0079639629 25.0087190814 67.6160286851 67.6170064935 30.4867482346
#> VZFP CLFO CLFP MRTEVLST MRTEVIFO
#> 30.4863228055 1.4772962667 1.4772756517 9.7974833547 20.8000305256
#> MRTEVIFP
#> 20.8003683211
#> attr(,"units")
#> [1] "" "mmol/L" "mmol/L/mg" "h" "h"
#> [6] "mmol/L" "mmol/L" "h" "h" "/h"
#> [11] "h" "h" "" "" ""
#> [16] "" "h*mmol/L" "h*mmol/L" "h*mmol/L" "h*mmol/L/mg"
#> [21] "h*mmol/L" "h*mmol/L/mg" "%" "%" "h2*mmol/L"
#> [26] "h2*mmol/L" "h2*mmol/L" "%" "%" "L"
#> [31] "L" "L/h" "L/h" "h" "h"
#> [36] "h"
#> attr(,"UsedPoints")
#> [1] 9 10 11
sNCA(x, y, dose=320/MW, doseUnit="mmol", concUnit="mg/L", timeUnit="h", MW=MW)
#> b0 CMAX CMAXD TMAX TLAG CLST
#> 2.3687851 10.5000000 5.9116312 1.1200000 0.0000000 3.2800000
#> CLSTP TLST LAMZHL LAMZ LAMZLL LAMZUL
#> 3.2801465 24.3700000 14.3043776 0.0484570 9.0500000 24.3700000
#> LAMZNPT CORRXY R2 R2ADJ AUCLST AUCALL
#> 3.0000000 -0.9999999 0.9999997 0.9999995 148.9230500 148.9230500
#> AUCIFO AUCIFOD AUCIFP AUCIFPD AUCPEO AUCPEP
#> 216.6119330 121.9552259 216.6149558 121.9569278 31.2489169 31.2498763
#> AUMCLST AUMCIFO AUMCIFP AUMCPEO AUMCPEP VZFO
#> 1459.0711035 4505.5348194 4505.6708646 67.6160287 67.6170065 30.4867482
#> VZFP CLFO CLFP MRTEVLST MRTEVIFO MRTEVIFP
#> 30.4863228 1.4772963 1.4772757 9.7974834 20.8000305 20.8003683
#> attr(,"units")
#> [1] "" "mg/L" "mg/L/mmol" "h" "h"
#> [6] "mg/L" "mg/L" "h" "h" "/h"
#> [11] "h" "h" "" "" ""
#> [16] "" "h*mg/L" "h*mg/L" "h*mg/L" "h*mg/L/mmol"
#> [21] "h*mg/L" "h*mg/L/mmol" "%" "%" "h2*mg/L"
#> [26] "h2*mg/L" "h2*mg/L" "%" "%" "L"
#> [31] "L" "L/h" "L/h" "h" "h"
#> [36] "h"
#> attr(,"UsedPoints")
#> [1] 9 10 11
sNCA(x, y/MW, dose=320/MW, doseUnit="mmol", concUnit="mmol/L", timeUnit="h", MW=MW)
#> b0 CMAX CMAXD TMAX TLAG CLST
#> -2.82508245 0.05828023 0.03281250 1.12000000 0.00000000 0.01820563
#> CLSTP TLST LAMZHL LAMZ LAMZLL LAMZUL
#> 0.01820645 24.37000000 14.30437757 0.04845700 9.05000000 24.37000000
#> LAMZNPT CORRXY R2 R2ADJ AUCLST AUCALL
#> 3.00000000 -0.99999986 0.99999973 0.99999946 0.82659716 0.82659716
#> AUCIFO AUCIFOD AUCIFP AUCIFPD AUCPEO AUCPEP
#> 1.20230420 0.67691229 1.20232097 0.67692174 31.24891694 31.24987633
#> AUMCLST AUMCIFO AUMCIFP AUMCPEO AUMCPEP VZFO
#> 8.09857188 25.00796396 25.00871908 67.61602869 67.61700649 30.48674823
#> VZFP CLFO CLFP MRTEVLST MRTEVIFO MRTEVIFP
#> 30.48632281 1.47729627 1.47727565 9.79748335 20.80003053 20.80036832
#> attr(,"units")
#> [1] "" "mmol/L" "mmol/L/mmol" "h"
#> [5] "h" "mmol/L" "mmol/L" "h"
#> [9] "h" "/h" "h" "h"
#> [13] "" "" "" ""
#> [17] "h*mmol/L" "h*mmol/L" "h*mmol/L" "h*mmol/L/mmol"
#> [21] "h*mmol/L" "h*mmol/L/mmol" "%" "%"
#> [25] "h2*mmol/L" "h2*mmol/L" "h2*mmol/L" "%"
#> [29] "%" "L" "L" "L/h"
#> [33] "L/h" "h" "h" "h"
#> attr(,"UsedPoints")
#> [1] 9 10 11
sNCA(x, y/MW, dose=320/MW, doseUnit="mmol", concUnit="mmol/L", timeUnit="h", MW=MW)
#> b0 CMAX CMAXD TMAX TLAG CLST
#> -2.82508245 0.05828023 0.03281250 1.12000000 0.00000000 0.01820563
#> CLSTP TLST LAMZHL LAMZ LAMZLL LAMZUL
#> 0.01820645 24.37000000 14.30437757 0.04845700 9.05000000 24.37000000
#> LAMZNPT CORRXY R2 R2ADJ AUCLST AUCALL
#> 3.00000000 -0.99999986 0.99999973 0.99999946 0.82659716 0.82659716
#> AUCIFO AUCIFOD AUCIFP AUCIFPD AUCPEO AUCPEP
#> 1.20230420 0.67691229 1.20232097 0.67692174 31.24891694 31.24987633
#> AUMCLST AUMCIFO AUMCIFP AUMCPEO AUMCPEP VZFO
#> 8.09857188 25.00796396 25.00871908 67.61602869 67.61700649 30.48674823
#> VZFP CLFO CLFP MRTEVLST MRTEVIFO MRTEVIFP
#> 30.48632281 1.47729627 1.47727565 9.79748335 20.80003053 20.80036832
#> attr(,"units")
#> [1] "" "mmol/L" "mmol/L/mmol" "h"
#> [5] "h" "mmol/L" "mmol/L" "h"
#> [9] "h" "/h" "h" "h"
#> [13] "" "" "" ""
#> [17] "h*mmol/L" "h*mmol/L" "h*mmol/L" "h*mmol/L/mmol"
#> [21] "h*mmol/L" "h*mmol/L/mmol" "%" "%"
#> [25] "h2*mmol/L" "h2*mmol/L" "h2*mmol/L" "%"
#> [29] "%" "L" "L" "L/h"
#> [33] "L/h" "h" "h" "h"
#> attr(,"UsedPoints")
#> [1] 9 10 11
sNCA(x, y/MW, doseUnit="mmol", concUnit="mmol/L", timeUnit="h", MW=MW)
#> b0 CMAX CMAXD TMAX TLAG CLST
#> -2.82508245 0.05828023 NA 1.12000000 0.00000000 0.01820563
#> CLSTP TLST LAMZHL LAMZ LAMZLL LAMZUL
#> 0.01820645 24.37000000 14.30437757 0.04845700 9.05000000 24.37000000
#> LAMZNPT CORRXY R2 R2ADJ AUCLST AUCALL
#> 3.00000000 -0.99999986 0.99999973 0.99999946 0.82659716 0.82659716
#> AUCIFO AUCIFOD AUCIFP AUCIFPD AUCPEO AUCPEP
#> 1.20230420 NA 1.20232097 NA 31.24891694 31.24987633
#> AUMCLST AUMCIFO AUMCIFP AUMCPEO AUMCPEP VZFO
#> 8.09857188 25.00796396 25.00871908 67.61602869 67.61700649 0.00000000
#> VZFP CLFO CLFP MRTEVLST MRTEVIFO MRTEVIFP
#> 0.00000000 0.00000000 0.00000000 9.79748335 20.80003053 20.80036832
#> attr(,"units")
#> [1] "" "mmol/L" "mmol/L/mmol" "h"
#> [5] "h" "mmol/L" "mmol/L" "h"
#> [9] "h" "/h" "h" "h"
#> [13] "" "" "" ""
#> [17] "h*mmol/L" "h*mmol/L" "h*mmol/L" "h*mmol/L/mmol"
#> [21] "h*mmol/L" "h*mmol/L/mmol" "%" "%"
#> [25] "h2*mmol/L" "h2*mmol/L" "h2*mmol/L" "%"
#> [29] "%" "L" "L" "L/h"
#> [33] "L/h" "h" "h" "h"
#> attr(,"UsedPoints")
#> [1] 9 10 11
sNCA(x, y/MW, dose=as.numeric(NA), doseUnit="mmol", concUnit="mmol/L", timeUnit="h",
MW=MW)
#> b0 CMAX CMAXD TMAX TLAG CLST
#> -2.82508245 0.05828023 NA 1.12000000 0.00000000 0.01820563
#> CLSTP TLST LAMZHL LAMZ LAMZLL LAMZUL
#> 0.01820645 24.37000000 14.30437757 0.04845700 9.05000000 24.37000000
#> LAMZNPT CORRXY R2 R2ADJ AUCLST AUCALL
#> 3.00000000 -0.99999986 0.99999973 0.99999946 0.82659716 0.82659716
#> AUCIFO AUCIFOD AUCIFP AUCIFPD AUCPEO AUCPEP
#> 1.20230420 NA 1.20232097 NA 31.24891694 31.24987633
#> AUMCLST AUMCIFO AUMCIFP AUMCPEO AUMCPEP VZFO
#> 8.09857188 25.00796396 25.00871908 67.61602869 67.61700649 NA
#> VZFP CLFO CLFP MRTEVLST MRTEVIFO MRTEVIFP
#> NA NA NA 9.79748335 20.80003053 20.80036832
#> attr(,"units")
#> [1] "" "mmol/L" "mmol/L/mmol" "h"
#> [5] "h" "mmol/L" "mmol/L" "h"
#> [9] "h" "/h" "h" "h"
#> [13] "" "" "" ""
#> [17] "h*mmol/L" "h*mmol/L" "h*mmol/L" "h*mmol/L/mmol"
#> [21] "h*mmol/L" "h*mmol/L/mmol" "%" "%"
#> [25] "h2*mmol/L" "h2*mmol/L" "h2*mmol/L" "%"
#> [29] "%" "L" "L" "L/h"
#> [33] "L/h" "h" "h" "h"
#> attr(,"UsedPoints")
#> [1] 9 10 11
sNCA(x, y, dose=320, concUnit="mg/L", timeUnit="hr")
#> b0 CMAX CMAXD TMAX TLAG CLST
#> 2.3687851 10.5000000 0.0328125 1.1200000 0.0000000 3.2800000
#> CLSTP TLST LAMZHL LAMZ LAMZLL LAMZUL
#> 3.2801465 24.3700000 14.3043776 0.0484570 9.0500000 24.3700000
#> LAMZNPT CORRXY R2 R2ADJ AUCLST AUCALL
#> 3.0000000 -0.9999999 0.9999997 0.9999995 148.9230500 148.9230500
#> AUCIFO AUCIFOD AUCIFP AUCIFPD AUCPEO AUCPEP
#> 216.6119330 0.6769123 216.6149558 0.6769217 31.2489169 31.2498763
#> AUMCLST AUMCIFO AUMCIFP AUMCPEO AUMCPEP VZFO
#> 1459.0711035 4505.5348194 4505.6708646 67.6160287 67.6170065 30.4867482
#> VZFP CLFO CLFP MRTEVLST MRTEVIFO MRTEVIFP
#> 30.4863228 1.4772963 1.4772757 9.7974834 20.8000305 20.8003683
#> attr(,"units")
#> [1] "" "mg/L" "mg/L/mg" "hr" "hr"
#> [6] "mg/L" "mg/L" "hr" "hr" "/hr"
#> [11] "hr" "hr" "" "" ""
#> [16] "" "hr*mg/L" "hr*mg/L" "hr*mg/L" "hr*mg/L/mg"
#> [21] "hr*mg/L" "hr*mg/L/mg" "%" "%" "hr2*mg/L"
#> [26] "hr2*mg/L" "hr2*mg/L" "%" "%" "L"
#> [31] "L" "L/hr" "L/hr" "hr" "hr"
#> [36] "hr"
#> attr(,"UsedPoints")
#> [1] 9 10 11
sNCA(x*60, y, dose=320, concUnit="mg/L", timeUnit="min")
#> b0 CMAX CMAXD TMAX TLAG
#> 2.368785e+00 1.050000e+01 3.281250e-02 6.720000e+01 0.000000e+00
#> CLST CLSTP TLST LAMZHL LAMZ
#> 3.280000e+00 3.280146e+00 1.462200e+03 8.582627e+02 8.076166e-04
#> LAMZLL LAMZUL LAMZNPT CORRXY R2
#> 5.430000e+02 1.462200e+03 3.000000e+00 -9.999999e-01 9.999997e-01
#> R2ADJ AUCLST AUCALL AUCIFO AUCIFOD
#> 9.999995e-01 8.935383e+03 8.935383e+03 1.299672e+04 4.061474e+01
#> AUCIFP AUCIFPD AUCPEO AUCPEP AUMCLST
#> 1.299690e+04 4.061530e+01 3.124892e+01 3.124988e+01 5.252656e+06
#> AUMCIFO AUMCIFP AUMCPEO AUMCPEP VZFO
#> 1.621993e+07 1.622042e+07 6.761603e+01 6.761701e+01 3.048675e+01
#> VZFP CLFO CLFP MRTEVLST MRTEVIFO
#> 3.048632e+01 2.462160e-02 2.462126e-02 5.878490e+02 1.248002e+03
#> MRTEVIFP
#> 1.248022e+03
#> attr(,"units")
#> [1] "" "mg/L" "mg/L/mg" "min" "min"
#> [6] "mg/L" "mg/L" "min" "min" "/min"
#> [11] "min" "min" "" "" ""
#> [16] "" "min*mg/L" "min*mg/L" "min*mg/L" "min*mg/L/mg"
#> [21] "min*mg/L" "min*mg/L/mg" "%" "%" "min2*mg/L"
#> [26] "min2*mg/L" "min2*mg/L" "%" "%" "L"
#> [31] "L" "L/min" "L/min" "min" "min"
#> [36] "min"
#> attr(,"UsedPoints")
#> [1] 9 10 11